Pain Reliever & Sleep Aid


Compare to Tylenol® PM

120 caplets
Relieves your minor aches and pains, while helping you fall asleep quickly for a good night's rest.
PainSleep Difficulty

Free carbon neutral shipping ($50+)

Refillable for life

FDA certified ingredients

Independently quality tested


  • Acetaminophen 500 mg (Pain reliever/fever reducer)
  • Diphenhydramine 25mg (Nighttime Sleep Aid)
  • One bottle, refillable for life. Shatter-tested and child safe, Cabinet’s stackable Pain Reliever & Sleep Aid bottle now comes prefilled with 120 caplets.

  • Ultimate peace of mind. Each batch of our medicines are quality tested by an independent lab, free of carcinogens and harmful additives, ensuring the highest possible quality.

  • Happier planet for generations to come. Ditching single-use plastic medicine bottles saves up to 1 lb of plastic annually from entering our oceans, landfills and air supply.

High quality & 
batch-level tested 
High quality & 
batch-level tested 
Sustainably produced & packaged
Sustainably produced & packaged
Space-saving & refillable bottles
Space-saving & refillable bottles
Compostable & commitment-free refills
Compostable & commitment-free refills

Meet the only


medicine system

PainFever PainSleep POUCH
Verified Medicines
Verified Medicines
A third party, independent lab tests all of our medicines to ensure you’re getting the highest quality active ingredients without any harmful filler.
The Future is Refillable
The Future is Refillable
We’re on a mission to eliminate single-use plastic from medicine with our refillable bottles and compostable refill pouches.*

Have questions?


The caps are made out of plastic. We are currently exploring using a plant-based plastic for these so that they can be recycled.

Cabinet pouches are made of 100% earth digestible (compostable) materials, specifically wood cellulose and biomaterials. They are also certified 100% backyard compostable and can be brought to local industrial or commercial composting facilities.

Cabinet refill pouches are made from wood cellulose and other biomaterials, all of which are 100% earth digestible. The pouches are back yard compostable, certified Lomi Approved, and municipal and industrial compostable (ASTM D6400).

You can buy our refillable bottles! Here is a link to where you can find them.


We know how important it is to know what you're putting inside your body. Please visit this link for a PDF of full drug facts for Cabinet Pain Relief + Sleep Aid.

It is important to check in with your doctor or healthcare provider before taking Cabinet Pain Reliever & Sleep Aid if you have liver disease, a breathing problem (such as emphysema or chronic bronchitis), glaucoma, or trouble urinating as a result of an enlarged prostate gland.

If you are currently taking a blood thinner called warfarin, sedatives, tranquilizers, sleeping pills, or any other medications that make you sleepy or have sedative effects, ask a doctor or local pharmacist prior to taking using this product.

In addition to its desired effects, Cabinet Pain Reliever & Sleep Aid may cause some less desirable side effects. While the acetaminophen component of this medicine does not really have any side effects, the diphenhydramine component does have some notable side effects. Everyone is different, so some people may experience no side effects at all, others may experience mild side effects, and a small number of people may experience rare or more serious adverse effects.

Some side effects of diphenhydramine include: dry mouth/nose/throat, sleepiness, dizziness, nausea and vomiting, loss of appetite, constipation, headache, nervousness, muscle weakness. Call your doctor immediately is you experience any vision problems, difficulty urinating, or painful urination. Some patients may experience side effects that are not on this list. Older adults may be more prone to the side effects of diphenhydramine. Check in with your health care provider or local pharmacist if you have questions or experience serious side effects.

Although rare, call 9-1-1 or seek medical help immediately if you develop a serious allergic reaction to this product. Symptoms of a very serious reaction include: rash, skin reddening, blisters, itching or swelling (usually in the face, tongue, and throat), severe dizziness, and difficulty breathing.

In the case of an overdose, contact a Poison Control Center (1-800-222-1222) or seek medical attention immediately. Signs of overdose may include: nausea and vomiting, loss of appetite, sweating, stomach pain, yellowing of the eyes/skin, dark urine, and extreme fatigue.

Cabinet Pain Reliever & Nighttime Sleep Aid, a generic alternative to Tylenol® PM (or acetaminophen PM), is an over-the-counter (OTC) combination pill used for the temporary relief of pain that is accompanied by sleeplessness. Each tablet contains two medicines, each working to relieve specific symptoms. How each individual ingredient works is explained below:

Acetaminophen: The active ingredient, acetaminophen, belongs to a group of medications called analgesics (pain relievers) and antipyretics (fever reducers). The exact way acetaminophen works in the body is not well known. It may work by decreasing the production of chemicals that cause inflammation, known as prostaglandins. It is also thought that acetaminophen can increase the pain threshold, making it so that more pain would have to develop for before you can feel it. Lastly, acetaminophen can act on the heat-regulating center of the brain (hypothalamus). When your temperature is high, it can tell this center of the brain to cool the body to bring your fever down. It is important to note acetaminophen does not decrease inflammation or swelling, rather it most likely changes the way your body perceives pain. This ingredient is available separately as Cabinet Pain Reliever & Fever Reducer.

Diphenhydramine: The active ingredient, diphenhydramine hcl, belongs to a group of medications called antihistamines. Antihistamines work by blocking the action of histamine, which is a substance in the body that causes allergic symptoms and reactions. Some antihistamines, such as diphenhydramine, can enter the brain and cause drowsiness. This side effect is what allows for diphenhydramine to be a great occasional, non-habit forming sleep aid. In addition to helping with sleep, this ingredient also works to relieve symptoms of allergy such as runny nose, sneezing, and watery eyes. Cabinet Pain Reliever and Nighttime Sleep Aid can provide relief for occasional sleeplessness, but is not used for long-term treatment of insomnia. This ingredient is available separately as Cabinet Sleep Aid and Cabinet Allergy Relief.

final 2 - tori petry cover
FAQs and Drug Facts Medically Reviewed by Medical Writing Team, Supported by PharmDs

The information on this page is a summary and is not intended to cover all available information about this medication. It does not cover all possible uses, directions, precautions, drug interactions or adverse effects and is not a substitute for the expertise and judgement of your healthcare professional. Consult your healthcare provider before starting or discontinuing any course of treatment.

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63 Reviews
  • AshleyAshley
    I LOVE what this company stands for

    Ingenious! Affordable start kit includes a very high quality glass container with magnetic top that is childproof. Refills come in recyclable packaging that is much less damaging to the earth than the traditional containers!!

  • SarahSarah
    obsessed !

    I purchased the pain reliever and sleep aid; the regular pain; reliever; daytime; severe; cold; and flu and nasal decongestant. I love how the containers are all reusable; and I am easily able to order the refills. all the information you need is right on the top of the container so you’re not looking around for a package!!

  • Meagan M.

    So Aesthetically pleasing; saves room and good quality medicine

  • DRSmithDRSmith
    Great for the environment; hard on your wallet

    My medicine cabinet was a mess with all the different boxes and bottles and random packaging from OTC and prescription meds. My son had a sinus infection that was making it difficult for him to sleep; but this Nighttime Pain Reliever and Sleep Aid for Headaches; Aches; and Pains from Cabinet did the trick. It was able to receive the pain from the sinus headache and allowed him to get some rest. The only downside is the price for the starter kit is more than the price for the name brand. I like the idea of cutting down on waste; but I also like the idea of not spending more than I need to for generic meds.

  • Melissa E.
    Works for me

    This is my favorite of all the medicines I stock from Cabinet Health. It truly works for me if I have any type of pain. It especially helps me at night to be relieved from pain enough to get some good sleep which is needed.