Daytime Severe Cold + Flu Starter Set

Refills from $8.00
Provides maximum strength non-drowsy relief of common cold and flu symptoms.
  • Acetaminophen 325 mg (Pain reliever/fever reducer)
  • Dextromethorphan HBr 10 mg (Cough suppressant)
  • Guaifenesin 200 mg (Expectorant)
  • Phenylephrine HCI 5 mg (Nasal decongestant)

Compare to DayQuil™ Severe

1 Set
30 day money-back guarantee | Free shipping over $45
  • 1 refillable child-safe glass medicine bottle

  • 1 compostable (municipal or industrial) refill pouch including:

    • 20 quality verified Daytime Severe Cold + Flu caplets, free of allergens, carcinogens and gluten

    • 1 magnetic label for Daytime Severe Cold + Flu made from 100% recyclable materials

    • Drug facts booklet for Daytime Severe Cold + Flu

High quality & 
batch-level tested 
High quality & 
batch-level tested 
Sustainably produced & packaged
Sustainably produced & packaged
Space-saving & refillable bottles
Space-saving & refillable bottles
Compostable & commitment-free refills
Compostable & commitment-free refills

Meet the only sustainable

medicine system

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100% Earth digestible
medicine refill pouches

Cabinet refill pouches are made from a blend of wood cellulose and biosealants to keep medicine fresh and safe. The materials are 100% compostable (compliant with ASTM D6400 guidelines) and digestable by the earth.

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Frequently Asked Questions


We know how important it is to know what you're putting inside your body. Please visit this link for a PDF of full drug facts for Cabinet Daytime Severe Cold + Flu.

For those with celiac disease or a gluten intolerance, we know how hard it can be to find safe medications and products you can trust. Cabinet is the first healthcare company to conduct batch-level quality testing through a 3rd party lab for carcinogens, gluten, and purity. This ensures that every batch of medicine that goes to market is high quality and free of harmful ingredients.

Cabinet Daytime Severe Cold + Flu is certified gluten-free and 100% free from known carcinogens. You can view our 3rd party certificate of analysis at this link.

For the curious consumer: Batch-level testing is not common practice among manufacturers. A great example of the lack of testing in this space is the massive Zanac (randitidine) recall in 2019 and 2020. Manufacturers recalled ranitidine (both brand and generic) after a cancer-causing chemical called N-Nitrosodimethylamine (NDMA) was discovered in every medicine lot.

Cabinet Daytime Cold & Flu Severe, a FDA-approved generic alternative to Tylenol® Cold & Flu Severe and Dayquil® Severe, is a popular over-the-counter (OTC) combination pill used for the temporary relief of common cold and flu symptoms. Each tablet contains four medicines, each working to relieve specific symptoms. How each individual ingredient works is explained below:

Acetaminophen: The active ingredient, acetaminophen, belongs to a group of medications called analgesics (pain relievers) and antipyretics (fever reducers). The exact way acetaminophen works in the body is not well known. It may work by decreasing the production of chemicals that cause inflammation, known as prostaglandins. It is also thought that acetaminophen can increase the pain threshold, making it so that more pain would have to develop for before you can feel it. Lastly, acetaminophen can act on the heat-regulating center of the brain (hypothalamus). When your temperature is high, it can tell this center of the brain to cool the body to bring your fever down. It is important to note acetaminophen does not decrease inflammation or swelling, rather it most likely changes the way your body perceives pain. This ingredient is available separately as Cabinet Pain Reliever & Fever Reducer.

Dextromethorphan: The active ingredient, dextromethorphan hydrobromide, belongs to a group of medications called antitussives (or cough suppressants). Dextromethorphan is able to cross into the cough center of the brain to suppress the cough reflex. This ingredient is available separately as Cabinet Cough Relief.

Guaifenesin: The active ingredient, guaifenesin, belongs to a group of medications called expectorants. Expectorants work by loosening and thinning phlegm (mucus) present in the lungs and airways. By decreasing the thickness and stickiness of the mucus, guaifenesin makes it easier to cough or spit out mucus from the throat and lungs. This ingredient is available separately as Cabinet Mucus Relief.

Phenylephrine: The active ingredient, phenylephrine, belongs to a group of medications called nasal decongestants. When blood vessels inside your nose expand, they start to swell and cause congestion. Nasal decongestants work by shrinking these blood vessels that are in the nasal passages to relieve symptoms. [It is important to note that phenylephrine differs from pseudoephedrine, which is the active ingredient in Sudafed.] This ingredient is available separately as Cabinet Nasal Decongestant.

Cabinet Daytime Severe Cold & Flu can be used for the temporary relief of cold and flu symptoms, such as minor body aches and pains, fever, headache, runny nose, sore throat, nasal congestion, sinus pressure, and cough. This product can also help loosen phlegm (mucus) and thin airway secretions to make it easier to cough or spit out phlegm.

Adults and children over the age of 12 can take two (2) caplets every four hours as needed for symptoms. The tablet should be taken with a full glass of water and can be taken with or without food. Do not take more than 10 caplets of Cabinet Daytime Severe Cold & Flu in 24 hours. This product is not approved for pediatric use and is not recommended for children under the age of 12, unless directed by a doctor. This product should be stored away from young children. In the case of an overdose, contact a Poison Control Center (1-800-222-1222) or seek medical attention immediately.

Liver Warning: This Cabinet Daytime Severe Cold & Flu contains acetaminophen. The maximum dose of this product is 10 caplets (or 3,250 mg of acetaminophen) in 24 hours. Severe liver damage may occur if you take more than 4,000 mg of acetaminophen in 24 hours. It is very important to watch out for other sources of acetaminophen and to make sure additive sources of acetaminophen do not go over 4,000 mg a day. Avoid consuming three or more alcoholic beverages every day while using this product.

Please speak with your doctor prior to using Cabinet Daytime Severe Cold & Flu if you are pregnant or breastfeeding. While some active ingredients in this product may be safe other active ingredients may not be the safest options.

You may notice the effects of Cabinet Daytime Severe Cold & Flu within 30 minutes of taking a dose. The effects of each dose can last up to four hours.

Cabinet Daytime Severe Cold & Flu is a non-drowsy medication. Guaifenesin, one of the active ingredients in this product, could cause mild drowsiness in some individuals when given alone. However, drowsiness is not commonly reported in this combination.

You should stop using Cabinet Daytime Severe Cold & Flu and seek medical advice from a health care professional if you experience:

  • Nervousness, dizziness, sleeplessless

  • Pain, nasal congestion, chest congestion, or cough that is worsening or lasts over seven days

  • Fever that is worsening or lasts over three days

  • Redness or swelling

  • New symptoms that present

  • Cough that returns or presents with a rash or headache that does not go away

These presentations could be signs of a more serious condition or infection.

It is recommended to limit or avoid alcohol while you are taking Cabinet Daytime Severe Cold & Flu. Try to space out the medicine and alcohol by at least six hours.

Please speak with your doctor prior to using Cabinet Daytime Severe Cold & Flu if you have:

  • Liver disease

  • Heart disease

  • High blood pressure

  • Thyroid disease

  • Diabetes

  • Trouble urinating due to an enlarged prostate gland

  • Persistent or chronic cough that occurs with smoking / asthma / chronic bronchitis / emphysema / other long-term breathing problems, or a cough that presents with too much phlegm (mucus).

Speak to your doctor or pharmacist before using this product if you are taking a medication called warfarin for your blood.

Avoid using Cabinet Daytime Severe Cold & Flu with any other prescription or over-the-counter medicine that contains acetaminophen. If you are not sure if a medicine has acetaminophen in it, check with a doctor or pharmacist.

It is also very important to avoid this product if you are currently taking a monoamine oxidase inhibitor (MAOI) or have taken a MAOI in the past two weeks. If you were on a MAOI before, make sure to wait at least two weeks before taking Cabinet Daytime Severe Cold & Flu. MAOIs (i.e. isocarboxazid, phenelzine, quinidine, rasagiline, selegiline, tranylcypromine) are a group of prescription drugs used to treat depression, psychiatric or emotional conditions, or Parkinson's disease. When some ingredients in this product are taken with a MAOI, very serious side effects may occur. If you are unsure if your prescription contains a MAOI, make sure to speak to your doctor or pharmacist before taking this medicine.

Lastly, avoid taking Cabinet Daytime Severe Cold & Flu if you have ever had an allergic reaction to any ingredient in this product.

In addition to its desired effects, Cabinet Daytime Severe Cold & Flu may cause some less desirable side effects. Everyone is different, so some people may experience no side effects at all, others may experience mild side effects, and a small number of people may experience rare or more serious adverse effects.

Some side effects of this product include: nervousness, drowsiness, dizziness, headache, trouble sleeping, and nausea or vomiting. Uncommon, but more serious side effects include: confusion, hallucinations, mental or mood changes, shaking, weakness, and difficulty urinating. Call 9-1-1 or seek immediate medical help if you experience chest pain and fast or irregular heartbeat. These are rare, but very serious side effects! Some patients may experience side effects that are not on this list. Check in with your health care provider or local pharmacist if you have questions or experience concerning side effects.

FAQs and Drug Facts Medically Reviewed by Joanna Tam, Healthcare and Content Manager
22 Reviews
  • Valeria G.

    This is amazing! Great product and packaging looks fantastic in your cabinet ;) So glad you guys are here! No worries expired meds and no more plastic in my bathroom 🎉

  • Mary P.
    They all work great

    Plus they are a real space saver and on the go there's definitely more I'm going to get for sure the pills does what it says !!!!

  • Sherry A.
    Daytime Severe Cold & Flu

    It works great. It helped with the aches and pains and helped me get thru the day.

  • Russell G.
    The coolest thing ever.

    The coolest thing ever.

  • Tyler M.
    Works just like the brand name

    Love that Cabinet does third party testing of their medicines. Makes me feel a lot more comfortable knowing they check for impurities!

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