Daytime Severe Cold & Flu


Compare to DayQuil™ Severe

30 caplets
Take care of your worst cold and flu symptoms like cough, nasal and chest congestion, fever, sore throat and body aches with Cabinet Daytime Severe Cold & Flu.

Free carbon neutral shipping ($50+)

Refillable for life

FDA certified ingredients

Independently quality tested


  • Acetaminophen 325 mg (Pain reliever/fever reducer)
  • Dextromethorphan HBr 10 mg (Cough suppressant)
  • Guaifenesin 200 mg (Expectorant)
  • Phenylephrine HCI 5 mg (Nasal decongestant)
  • One bottle, refillable for life. Shatter-tested and child safe, Cabinet’s stackable Daytime Severe Cold & Flu bottle now comes prefilled with 30 caplets.

  • Ultimate peace of mind. Each batch of our medicines are quality tested by an independent lab, free of carcinogens and harmful additives, ensuring the highest possible quality.

  • Happier planet for generations to come. Ditching single-use plastic medicine bottles saves up to 1 lb of plastic annually from entering our oceans, landfills and air supply.

High quality & 
batch-level tested 
High quality & 
batch-level tested 
Sustainably produced & packaged
Sustainably produced & packaged
Space-saving & refillable bottles
Space-saving & refillable bottles
Compostable & commitment-free refills
Compostable & commitment-free refills

Meet the only


medicine system

ColdFlu DaytimeSevere POUCH
Verified Medicines
Verified Medicines
A third party, independent lab tests all of our medicines to ensure you’re getting the highest quality active ingredients without any harmful filler.
The Future is Refillable
The Future is Refillable
We’re on a mission to eliminate single-use plastic from medicine with our refillable bottles and compostable refill pouches.*

Have questions?


The caps are made out of plastic. We are currently exploring using a plant-based plastic for these so that they can be recycled.

Cabinet pouches are made of 100% earth digestible (compostable) materials, specifically wood cellulose and biomaterials. They are also certified 100% backyard compostable and can be brought to local industrial or commercial composting facilities.

Cabinet refill pouches are made from wood cellulose and other biomaterials, all of which are 100% earth digestible. The pouches are back yard compostable, certified Lomi Approved, and municipal and industrial compostable (ASTM D6400).

You can buy our refillable bottles! Here is a link to where you can find them.


We know how important it is to know what you're putting inside your body. Please visit this link for a PDF of full drug facts for Cabinet Daytime Severe Cold + Flu.

Avoid using Cabinet Daytime Severe Cold & Flu with any other prescription or over-the-counter medicine that contains acetaminophen. If you are not sure if a medicine has acetaminophen in it, check with a doctor or pharmacist.

It is also very important to avoid this product if you are currently taking a monoamine oxidase inhibitor (MAOI) or have taken a MAOI in the past two weeks. If you were on a MAOI before, make sure to wait at least two weeks before taking Cabinet Daytime Severe Cold & Flu. MAOIs (i.e. isocarboxazid, phenelzine, quinidine, rasagiline, selegiline, tranylcypromine) are a group of prescription drugs used to treat depression, psychiatric or emotional conditions, or Parkinson's disease. When some ingredients in this product are taken with a MAOI, very serious side effects may occur. If you are unsure if your prescription contains a MAOI, make sure to speak to your doctor or pharmacist before taking this medicine.

Lastly, avoid taking Cabinet Daytime Severe Cold & Flu if you have ever had an allergic reaction to any ingredient in this product.

In addition to its desired effects, Cabinet Daytime Severe Cold & Flu may cause some less desirable side effects. Everyone is different, so some people may experience no side effects at all, others may experience mild side effects, and a small number of people may experience rare or more serious adverse effects.

Some side effects of this product include: nervousness, drowsiness, dizziness, headache, trouble sleeping, and nausea or vomiting. Uncommon, but more serious side effects include: confusion, hallucinations, mental or mood changes, shaking, weakness, and difficulty urinating. Call 9-1-1 or seek immediate medical help if you experience chest pain and fast or irregular heartbeat. These are rare, but very serious side effects! Some patients may experience side effects that are not on this list. Check in with your health care provider or local pharmacist if you have questions or experience concerning side effects.

Cabinet Daytime Cold & Flu Severe, a FDA-approved generic alternative to Tylenol® Cold & Flu Severe and Dayquil® Severe, is a popular over-the-counter (OTC) combination pill used for the temporary relief of common cold and flu symptoms. Each tablet contains four medicines, each working to relieve specific symptoms. How each individual ingredient works is explained below:

Acetaminophen: The active ingredient, acetaminophen, belongs to a group of medications called analgesics (pain relievers) and antipyretics (fever reducers). The exact way acetaminophen works in the body is not well known. It may work by decreasing the production of chemicals that cause inflammation, known as prostaglandins. It is also thought that acetaminophen can increase the pain threshold, making it so that more pain would have to develop for before you can feel it. Lastly, acetaminophen can act on the heat-regulating center of the brain (hypothalamus). When your temperature is high, it can tell this center of the brain to cool the body to bring your fever down. It is important to note acetaminophen does not decrease inflammation or swelling, rather it most likely changes the way your body perceives pain. This ingredient is available separately as Cabinet Pain Reliever & Fever Reducer.

Dextromethorphan: The active ingredient, dextromethorphan hydrobromide, belongs to a group of medications called antitussives (or cough suppressants). Dextromethorphan is able to cross into the cough center of the brain to suppress the cough reflex. This ingredient is available separately as Cabinet Cough Relief.

Guaifenesin: The active ingredient, guaifenesin, belongs to a group of medications called expectorants. Expectorants work by loosening and thinning phlegm (mucus) present in the lungs and airways. By decreasing the thickness and stickiness of the mucus, guaifenesin makes it easier to cough or spit out mucus from the throat and lungs. This ingredient is available separately as Cabinet Mucus Relief.

Phenylephrine: The active ingredient, phenylephrine, belongs to a group of medications called nasal decongestants. When blood vessels inside your nose expand, they start to swell and cause congestion. Nasal decongestants work by shrinking these blood vessels that are in the nasal passages to relieve symptoms. [It is important to note that phenylephrine differs from pseudoephedrine, which is the active ingredient in Sudafed.] This ingredient is available separately as Cabinet Nasal Decongestant.

FAQs and Drug Facts Medically Reviewed by Joanna Tam, Lead Pharmacist | PharmD

The information on this page is a summary and is not intended to cover all available information about this medication. It does not cover all possible uses, directions, precautions, drug interactions or adverse effects and is not a substitute for the expertise and judgement of your healthcare professional. Consult your healthcare provider before starting or discontinuing any course of treatment.

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45 Reviews
  • Michael f.

    Used recently and was an effective medication.

  • Susan G.
    It really works

    This is the best severe Cold and Flu pills.

  • Jessie D.
    compares to dayquil

    I switched to cabinethealth a while back and it does just as good as a job as dayquil does. I also love that it’s in a reusable bottle!

  • Samantha J.
    Great quality

    I love the packaging a refillability of these medications. They also work really well!

  • Emily C.
    Great product

    Love these! I had a cold and it came just in time. Medicine worked great and I love the packaging.