Your Prescription, Our Promise: See How Much Plastic Waste You'll Save With Cabinet®

Your Prescription, Our Promise: Eco-Friendly Glass Bottles for a Cleaner Planet. Learn how you can reduce your plastic footprint & micro-plastic consumption.



How old are you?

Please enter your age and number of prescriptions you take.

See if Your Prescriptions Qualify for a Free Personalized Glass Bottle & Automated Refills.

Search for one of your prescriptions to find out whether you can get a free personalized glass bottle that's refillable for life (no more orange plastic) & automated refills shipped to your home.

Naproxen and metformin are commonly prescribed medications for different conditions. While it may be tempting to mix them, it is important to understand the potential interactions and risks involved. In this article, we will explore the facts about naproxen and metformin, their mechanisms of action, possible side effects of combining them, and alternative options to consider.

Understanding Naproxen and Metformin

What is Naproxen?

Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) that is used to relieve pain, reduce inflammation, and lower fever. It is commonly prescribed for conditions such as arthritis, menstrual cramps, and acute muscle pain.

When it comes to arthritis, naproxen can be particularly beneficial. Arthritis is a condition characterized by inflammation of the joints, which can cause pain, stiffness, and swelling. By inhibiting the production of prostaglandins, naproxen helps to reduce inflammation and provide relief from these symptoms.

Furthermore, naproxen is often used to alleviate menstrual cramps. Menstrual cramps, also known as dysmenorrhea, can be extremely uncomfortable and painful for many women. The anti-inflammatory properties of naproxen can help to ease the pain associated with these cramps, allowing women to go about their daily activities without disruption.

In addition to its use for arthritis and menstrual cramps, naproxen is also effective in treating acute muscle pain. Whether it's due to an injury, overexertion, or a strenuous workout, muscle pain can be debilitating. Naproxen works by reducing the inflammation in the affected muscles, providing relief and allowing for a quicker recovery.

What is Metformin?

Metformin, on the other hand, is an oral medication that is primarily used to treat type 2 diabetes. It helps to control blood sugar levels by reducing the amount of glucose produced by the liver and increasing the sensitivity of muscle and fat cells to insulin.

Managing type 2 diabetes can be a complex task, but metformin plays a crucial role in its treatment. By reducing the production of glucose by the liver, metformin helps to lower blood sugar levels and maintain them within a healthy range. Additionally, it improves the body's response to insulin, a hormone that regulates glucose uptake by cells. This increased sensitivity to insulin allows muscle and fat cells to effectively utilize glucose, further aiding in blood sugar control.

While metformin is primarily used for diabetes management, it has also shown potential benefits in other areas. One such area is polycystic ovary syndrome (PCOS), a hormonal disorder that affects many women. Metformin can help regulate the hormonal imbalances associated with PCOS, leading to improved menstrual regularity and fertility.

Furthermore, metformin has been explored as a potential aid in weight management. Some studies suggest that metformin may help individuals with obesity or overweight to lose weight and improve their overall metabolic health. It is believed that metformin's effects on insulin sensitivity and glucose metabolism contribute to these potential weight-related benefits.

The Mechanism of Action

How Does Naproxen Work?

Naproxen, a nonsteroidal anti-inflammatory drug (NSAID), works by inhibiting the activity of enzymes called cyclooxygenases (COX-1 and COX-2). These enzymes are involved in the production of prostaglandins, which are lipid compounds that play a key role in inflammation and pain signaling.

When tissue is injured or damaged, prostaglandins are released, causing blood vessels to dilate and become more permeable. This leads to the characteristic signs of inflammation, such as redness, swelling, and pain. By blocking the action of COX enzymes, naproxen reduces the production of prostaglandins, thereby alleviating inflammation and relieving pain.

It is important to note that naproxen is not a selective COX-2 inhibitor, which means that it can affect both COX-1 and COX-2 enzymes. COX-1 is constitutively expressed in many tissues and is involved in maintaining normal physiological functions, such as protecting the stomach lining and promoting blood clotting. In contrast, COX-2 is induced during inflammation and is primarily responsible for the production of prostaglandins involved in pain and inflammation. By inhibiting both COX-1 and COX-2, naproxen provides broad anti-inflammatory and analgesic effects.

How Does Metformin Work?

Metformin, an oral medication commonly used to treat type 2 diabetes, works through multiple mechanisms to improve blood glucose control and insulin sensitivity.

One of the key mechanisms of metformin involves targeting and activating an enzyme called AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor that plays a crucial role in regulating energy metabolism and glucose uptake in cells. When cellular energy levels are low, such as during fasting or exercise, AMPK is activated to promote glucose uptake and utilization, while inhibiting energy-consuming processes.

By activating AMPK, metformin helps to lower blood glucose levels by increasing glucose uptake in skeletal muscle and reducing glucose production in the liver. This improves insulin sensitivity, allowing cells to respond more effectively to insulin and facilitating glucose uptake into tissues.

Additionally, metformin has been shown to have effects on various other pathways in the body. It has been found to reduce liver fat accumulation, which is beneficial in individuals with non-alcoholic fatty liver disease (NAFLD). Metformin also has appetite-suppressing effects, leading to potential weight loss in some individuals.

Furthermore, studies suggest that metformin may have anti-cancer properties, as it has been shown to inhibit the growth of certain cancer cells and reduce the risk of cancer development in individuals with diabetes.

In summary, metformin's multifaceted mechanism of action makes it a valuable medication for the management of type 2 diabetes, with potential benefits beyond glycemic control.

Potential Interactions Between Naproxen and Metformin

Possible Side Effects of Mixing Naproxen and Metformin

While naproxen and metformin are generally safe when taken as prescribed, combining them can increase the risk of certain side effects. One potential interaction is gastrointestinal bleeding, as both medications can irritate the stomach lining. It is important to be cautious if you have a history of stomach ulcers or bleeding disorders.

In addition, taking naproxen and metformin together may affect kidney function. Both medications can have potential renal side effects, such as decreased kidney function or fluid retention. If you have pre-existing kidney disease or are at risk for kidney problems, it is essential to discuss the potential risks with your healthcare provider.

Risks of Combining These Medications

Another risk associated with combining naproxen and metformin is the potential for drug interactions. Naproxen can interfere with the renal clearance of metformin, leading to an increase in metformin levels in the body. This can increase the risk of metformin-related side effects such as lactic acidosis.

It is important to note that the risks and severity of interactions may vary depending on individual factors such as age, overall health, and the dosage of the medications. Therefore, it is crucial to consult your doctor before making any changes to your medication regimen.

Medical Advice on Drug Interactions

When to Consult Your Doctor

If you are considering taking naproxen and metformin together or have been prescribed both medications, it is important to consult your healthcare provider. Your doctor will be able to evaluate your medical history, current medications, and overall health condition to determine the best course of action.

Your doctor may recommend alternative pain relief options if you are taking metformin for diabetes management. They may also adjust the dosages or closely monitor your kidney function and blood glucose levels to minimize the risk of any potential interactions.

Safe Practices for Taking Medications

Regardless of whether you mix naproxen and metformin or take them separately, it is important to follow safe practices when taking medications. Always take your medications as prescribed by your healthcare provider and adhere to the recommended dosages and schedules.

Make sure to inform your doctor about all the medications, including over-the-counter drugs and herbal supplements, that you are currently taking. This will help them assess potential interactions and adjust your treatment plan accordingly. Additionally, be aware of any possible side effects and consult your healthcare provider if you experience any concerning symptoms.

TryYour Name!Directions: Actualdirections will reflect your prescription once Transfered.ESCITALOPRAM 20mgRX# 105114PRESCRIBED BYDOCTOR

Goodbye, Orange Plastic—Hello, Elegant Glass: The Future of Prescriptions is Clear

Alternatives to Mixing Naproxen and Metformin

Other Pain Relievers Compatible with Metformin

If you are taking metformin for diabetes management and need pain relief, there are alternative options available. Non-NSAID pain relievers such as acetaminophen (paracetamol) can be a suitable choice. Acetaminophen is generally considered safe to use alongside metformin, but it is still important to consult your doctor for personalized advice.

Diabetes Medications That Can Be Taken with Naproxen

If you require both naproxen and metformin for different medical reasons, your healthcare provider may consider alternative diabetes medications that do not have a significant interaction with naproxen. There are several different classes of diabetes medications available, and your doctor will be able to determine the most appropriate option for you.


While naproxen and metformin are both commonly prescribed medications, it is important to understand the potential interactions and risks involved in mixing them. Gastrointestinal bleeding, kidney function impairment, and drug interactions are among the concerns that should be considered. Always consult your doctor before making any changes to your medication regimen and follow safe practices for taking medications. There are alternative options available if you need pain relief while taking metformin or alternative diabetes medications if you require naproxen for non-diabetes-related conditions.

Your healthcare provider is the best source of information and can provide personalized advice based on your specific situation. It is always better to be cautious and well-informed when it comes to your health and medication choices.