Glyburide/Metformin 5/500mg is a combination medication used to manage type 2 diabetes. This article delves into the specifics of this medication, its uses, side effects, and precautions to consider when taking it.

What is Glyburide/Metformin 5/500mg?

Glyburide/Metformin 5/500mg is a prescription medication that combines two drugs, Glyburide and Metformin. Both of these drugs are oral antihyperglycemic agents that are used to control high blood sugar in people with type 2 diabetes.

Glyburide belongs to a class of drugs known as sulfonylureas. It works by stimulating the pancreas to produce more insulin. Metformin, on the other hand, is a biguanide. It works by decreasing the amount of glucose produced by the liver and improving the body's response to insulin.

Uses of Glyburide/Metformin 5/500mg

This combination medication is used along with a proper diet and exercise program to control high blood sugar in people with type 2 diabetes. It is used when diet and exercise alone does not result in the desired blood sugar control.

Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke.

How to Take Glyburide/Metformin 5/500mg

Glyburide/Metformin 5/500mg is taken by mouth, usually once or twice a day with meals. The dosage is based on your medical condition, response to treatment, and other medications you may be taking.

It's important to take this medication regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day. It's also crucial to continue taking this medication even if you feel well.

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Side Effects of Glyburide/Metformin 5/500mg

Like any medication, Glyburide/Metformin 5/500mg can cause side effects. Common side effects include nausea, upset stomach, or diarrhea. These symptoms usually occur during the first few weeks of treatment and go away as your body adjusts to the medication.

However, if these side effects persist or worsen, it's important to inform your doctor or pharmacist promptly. Serious side effects are rare but can include new signs of infection, unusual tiredness, or sudden weight gain.

Precautions When Taking Glyburide/Metformin 5/500mg

Before starting Glyburide/Metformin 5/500mg, tell your doctor or pharmacist if you are allergic to either of the drugs, or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems.

Furthermore, this medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: severe kidney disease, severe liver disease, certain hormonal conditions (adrenal/pituitary insufficiency, syndrome of inappropriate secretion of antidiuretic hormone), or a certain condition with a high blood acid level (metabolic acidosis).

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Interactions with Glyburide/Metformin 5/500mg

Drug interactions can change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist.

Do not start, stop, or change the dosage of any medicines without your doctor's approval. A product that may interact with this drug is: dofetilide.


Glyburide/Metformin 5/500mg is a crucial medication for managing type 2 diabetes. However, like any medication, it should be taken under the guidance of a healthcare professional. Always consult your doctor or pharmacist before starting or stopping any medication.

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