Desvenlafaxine ER (generic for Pristiq®)

FDA Approved

Have a prescription? Get your Desvenlafaxine ER (Pristiq®) refills in sustainable packaging with Cabinet Health.
  • Desvenlafaxine Succinate ER

Generic For Pristiq®

Medication Type:
Medication Strengths:
How Many Do You Take A Day?
Day Supply:
Save $6 + 2 shipments with 90 day supply
Total Count: 30 tablets
To see your bottle rendered, type your full name:
Hi! Want to see what your personalized bottle would look like?
30 day money-back guarantee | Free shipping over $50

How does Cabinet care for you?

  1. Seamless transfer process. Our pharmacist will coordinate with your current pharmacy or provider to transfer your prescription.

  2. Better for the planet. Our pharmacy will send your prescription refills in plastic-free, compostable pouches.

  3. Stress-free refills. Our care team will help manage your refills and prescription renewals, so you don't have to worry about running out of pills.

  4. Satisfaction guarantee. If your care needs aren't being met, our care team is here and eager to help! If you're not satisfied, we can transfer your prescription back to your old pharmacy at any time.

Doctor illustration - prescription

Have a specific

Speak with a Pharmacist

Meet the only sustainable

medicine system

CAB-10027-Pain-Reliever- -Fever-Reducer-Acet-action-centered-sRGB-system-visualized-mobile-q=90-label
Compostable Refills
Compostable Refills
Eliminate excessive plastic waste with each refill and compost the packaging!
A Sustainable Pharmacy
A Sustainable Pharmacy
We created a pharmacy focused on reducing plastic and medical waste
Transforming the medicine industry!
A new way of buying medications
Sustainable and elevated

Frequently Asked Questions

About the Drug

Desvenlafaxine is the generic equivalent of Pristiq®. This drug only comes in the form of extended-release tablets.

By law, a generic drug must be the same as its brand name counterpart in terms of active ingredient, dosage, safety, effectiveness, strength, stability, and quality. A generic may, however, differ in its inactive ingredients (i.e. flavoring, fillers, and preservatives).

Desvenlafaxine ER (Pristiq®) does come with serious warnings. These include:

  • Increased risk of suicidal thoughts or actions*

  • Serotonin syndrome—a rare, but potentially life-threatening condition that occurs when there’s too much serotonin in the brain

  • High blood pressure or changes in blood pressure—must be monitored periodically

  • Increased risk of bleeding, bleeding problems

  • Angle-closure glaucoma

  • Manic episodes or hypomania in patients with bipolar disorder

  • Risk of high cholesterol and triglyceride levels

  • Withdrawal symptoms—abrupt discontinuation of treatment can cause nausea, anxiety, confusion, and headache

  • Seizure

  • Lung disease and pneumonia

If any of the above concern you, speak with your doctor or pharmacist about your perceived risk and other treatment options that exist.

*This warning is a boxed warning. A boxed warning is the most serious type of medication warning assigned by the FDA.

Desvenlafaxine is an SNRI (serotonin-norepinephrine reuptake inhibitor). It works by blocking the brain’s absorption of norepinephrine and serotonin, “feed good” chemicals in your brain. The end result? An increased level of norepinephrine and serotonin in your brain, which is thought to improve mood and pain.

Desvenlafaxine is FDA approved for the treatment of:

  • Major depressive disorder (MDD) or depression

Desvenlafaxine may also be used off-label for:

  • Hot flashes during menopause

  • Generalized anxiety

  • Social anxiety

  • Panic attacks

The most common side effects of desvenlafaxine include:

  • Nausea/vomiting

  • Dizziness

  • Trouble sleeping

  • Tiredness

  • Excessive sweating (hyperhidrosis)

  • Constipation

  • Decreased appetitie

  • Anxiety

  • Sexual dysfunction in males

  • Decreased sex drive

  • Dry mouth

Side effects may improve over time as your body adjusts to the medicine.

This list doesn’t represent all possible side effects (or serious side effects) of desvenlafaxine. If you’re experiencing any ongoing, bothersome side effect(s), tell your healthcare provider right away.

If you’d like to learn more, speak with your doctor or pharmacist. The Food and Drug Administration (FDA) also has a helpful medication guide for desvenlafaxine here.

Frequently Asked Questions

Desvenlafaxine can interact with some prescription drugs and supplements. It’s always recommended to give both your doctor and pharmacy an updated list of everything you’re taking, so drug interactions can be identified.

Some medicines and supplements desvenlafaxine can interact with include:

  • SSRIs (selective serotonin reuptake inhibitors): citalopram, sertraline, fluoxetine, paroxetine

  • Monoamine oxidase inhibitors (MAOIs): selegiline, phenelzine, linezolid, methylene blue, tranylcypromine, isocarboxazid

  • SNRIs (serotonin and norepinephrine reuptake inhibitors): venlafaxine (Effexor),, duloxetine, milnacipran

  • Triptans: sumatriptan, eletriptan, naratriptan

  • Arrhythmia medications: propafenone, flecainide

  • Alcohol

  • Buspirone

  • NSAIDs (nonsteroidal anti-inflammatory drugs): aspirin, ibuprofen

  • Warfarin

  • Lithium

  • Tramadol

  • Cimetidine

  • St. John’s Wort

  • Ciprofloxacin

  • Weight loss medications

  • Amphetamines

This list doesn’t represent all the drugs that may not be safe to take with desvenlafaxine. If you’re unsure whether a certain drug or supplement can be taken with desvenlafaxine, seek medical advice from your doctor or pharmacist. The FDA also has a helpful medication guide for desvenlafaxine here.

If you accidentally miss your dose of desvenlafaxine, take the dose as soon as you remember. If it’s almost time for your next dose, skip the missed dose and take your next dose at the usual time. Don't take 2 doses at the same time or extra doses.

Desvenlafaxine may be taken with or without food.

During pregnancy: Limited data exists on the effects of desvenlafaxine-use during pregnancy. According to some data, newborns who were exposed to antipsychotic drugs during the 3rd trimester of pregnancy may be at risk for experiencing withdrawal symptoms following delivery.

While breastfeeding: Desvenlafaxine is excreted in breastmilk and there is a risk for serious adverse reactions in nursing infants.

It’s important to treat mental health-related conditions when pregnant or nursing, as untreated depression, anxiety, or other mental illnesses can harm both you and baby. Always let your provider know if you’re pregnant or breastfeeding, so you can discuss alternative treatment options.

It’s recommended to avoid or limit the use of alcohol when taking desvenlafaxine. Drinking alcohol can intensify the side effects of desvenlafaxine, including dizziness, mental impairment and sleepiness.


All prescriptions are filled at HealthHavenRx - our partner pharmacy and the only pharmacy that can fill prescriptions in our sustainable pouches! If you need to contact them, please call them at the number below.


Toll-Free: 1-877-289-2839

1 Chestnut Street, Suite 3Y
Nashua, NH 03060​


Toll-Free: 1-877-289-2839

1 Chestnut Street, Suite 3Y
Nashua, NH 03060​

A prescription transfer is what happens when you switch pharmacies. During the transfer process our partner pharmacy will contact your existing pharmacy to move your prescription over.

For now, we partner with a cash-pay only pharmacy. In many situations the prices are less than your copay!

Not yet, but we're working on it! In the meantime, you can place and order and get a receipt from your account portal to send in for reimbursement.

Absolutely! Please email our pharmacy team at and we'll get right back to you.

Generally, our partner pharmacy can fill most non-controlled, oral dose prescriptions in Cabinet's compostable refill pouches. They currently do not fill liquid, cream, or compounded medications. We'll contact you directly if the pharmacy has any issue transferring your prescription.

FAQs and Drug Facts Medically Reviewed by Joanna Tam, Lead Pharmacist, PharmD

Disclaimer: The information on this page is a summary and is not intended to cover all available information about this medication. It does not cover all possible uses, directions, precautions, drug interactions, or adverse effects and is not a substitute for the expertise and judgment of your healthcare professional. Consult your healthcare provider before starting or discontinuing any course of treatment.

Sustainable Healthcare Stamp