Daytime Severe Cold & Flu


Compare to DayQuil™ Severe

30 caplets
Take care of your worst cold and flu symptoms like cough, nasal and chest congestion, fever, sore throat and body aches with Cabinet Daytime Severe Cold & Flu.

Free carbon neutral shipping ($50+)

Refillable for life

FDA certified ingredients

Independently quality tested


  • Acetaminophen 325 mg (Pain reliever/fever reducer)
  • Dextromethorphan HBr 10 mg (Cough suppressant)
  • Guaifenesin 200 mg (Expectorant)
  • Phenylephrine HCI 5 mg (Nasal decongestant)
  • One bottle, refillable for life. Shatter-tested and child safe, Cabinet’s stackable Daytime Severe Cold & Flu bottle now comes prefilled with 30 caplets.

  • Ultimate peace of mind. Each batch of our medicines are quality tested by an independent lab, free of carcinogens and harmful additives, ensuring the highest possible quality.

  • Happier planet for generations to come. Ditching single-use plastic medicine bottles saves up to 1 lb of plastic annually from entering our oceans, landfills and air supply.

High quality & 
batch-level tested 
High quality & 
batch-level tested 
Sustainably produced & packaged
Sustainably produced & packaged
Space-saving & refillable bottles
Space-saving & refillable bottles
Compostable & commitment-free refills
Compostable & commitment-free refills

Meet the only


medicine system

ColdFlu DaytimeSevere POUCH
Verified Medicines
Verified Medicines
A third party, independent lab tests all of our medicines to ensure you’re getting the highest quality active ingredients without any harmful filler.
The Future is Refillable
The Future is Refillable
We’re on a mission to eliminate single-use plastic from medicine with our refillable bottles and compostable refill pouches.*

Have questions?


The caps are made out of plastic. We are currently exploring using a plant-based plastic for these so that they can be recycled.

Cabinet pouches are made of 100% earth digestible (compostable) materials, specifically wood cellulose and biomaterials. They are also certified 100% backyard compostable and can be brought to local industrial or commercial composting facilities.

Cabinet refill pouches are made from wood cellulose and other biomaterials, all of which are 100% earth digestible. The pouches are back yard compostable, certified Lomi Approved, and municipal and industrial compostable (ASTM D6400).

You can buy our refillable bottles! Here is a link to where you can find them.


We know how important it is to know what you're putting inside your body. Please visit this link for a PDF of full drug facts for Cabinet Daytime Severe Cold + Flu.

Avoid using Cabinet Daytime Severe Cold & Flu with any other prescription or over-the-counter medicine that contains acetaminophen. If you are not sure if a medicine has acetaminophen in it, check with a doctor or pharmacist.

It is also very important to avoid this product if you are currently taking a monoamine oxidase inhibitor (MAOI) or have taken a MAOI in the past two weeks. If you were on a MAOI before, make sure to wait at least two weeks before taking Cabinet Daytime Severe Cold & Flu. MAOIs (i.e. isocarboxazid, phenelzine, quinidine, rasagiline, selegiline, tranylcypromine) are a group of prescription drugs used to treat depression, psychiatric or emotional conditions, or Parkinson's disease. When some ingredients in this product are taken with a MAOI, very serious side effects may occur. If you are unsure if your prescription contains a MAOI, make sure to speak to your doctor or pharmacist before taking this medicine.

Lastly, avoid taking Cabinet Daytime Severe Cold & Flu if you have ever had an allergic reaction to any ingredient in this product.

In addition to its desired effects, Cabinet Daytime Severe Cold & Flu may cause some less desirable side effects. Everyone is different, so some people may experience no side effects at all, others may experience mild side effects, and a small number of people may experience rare or more serious adverse effects.

Some side effects of this product include: nervousness, drowsiness, dizziness, headache, trouble sleeping, and nausea or vomiting. Uncommon, but more serious side effects include: confusion, hallucinations, mental or mood changes, shaking, weakness, and difficulty urinating. Call 9-1-1 or seek immediate medical help if you experience chest pain and fast or irregular heartbeat. These are rare, but very serious side effects! Some patients may experience side effects that are not on this list. Check in with your health care provider or local pharmacist if you have questions or experience concerning side effects.

Cabinet Daytime Cold & Flu Severe, a FDA-approved generic alternative to Tylenol® Cold & Flu Severe and Dayquil® Severe, is a popular over-the-counter (OTC) combination pill used for the temporary relief of common cold and flu symptoms. Each tablet contains four medicines, each working to relieve specific symptoms. How each individual ingredient works is explained below:

Acetaminophen: The active ingredient, acetaminophen, belongs to a group of medications called analgesics (pain relievers) and antipyretics (fever reducers). The exact way acetaminophen works in the body is not well known. It may work by decreasing the production of chemicals that cause inflammation, known as prostaglandins. It is also thought that acetaminophen can increase the pain threshold, making it so that more pain would have to develop for before you can feel it. Lastly, acetaminophen can act on the heat-regulating center of the brain (hypothalamus). When your temperature is high, it can tell this center of the brain to cool the body to bring your fever down. It is important to note acetaminophen does not decrease inflammation or swelling, rather it most likely changes the way your body perceives pain. This ingredient is available separately as Cabinet Pain Reliever & Fever Reducer.

Dextromethorphan: The active ingredient, dextromethorphan hydrobromide, belongs to a group of medications called antitussives (or cough suppressants). Dextromethorphan is able to cross into the cough center of the brain to suppress the cough reflex. This ingredient is available separately as Cabinet Cough Relief.

Guaifenesin: The active ingredient, guaifenesin, belongs to a group of medications called expectorants. Expectorants work by loosening and thinning phlegm (mucus) present in the lungs and airways. By decreasing the thickness and stickiness of the mucus, guaifenesin makes it easier to cough or spit out mucus from the throat and lungs. This ingredient is available separately as Cabinet Mucus Relief.

Phenylephrine: The active ingredient, phenylephrine, belongs to a group of medications called nasal decongestants. When blood vessels inside your nose expand, they start to swell and cause congestion. Nasal decongestants work by shrinking these blood vessels that are in the nasal passages to relieve symptoms. [It is important to note that phenylephrine differs from pseudoephedrine, which is the active ingredient in Sudafed.] This ingredient is available separately as Cabinet Nasal Decongestant.

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FAQs and Drug Facts Medically Reviewed by Medical Writing Team, Supported by PharmDs

The information on this page is a summary and is not intended to cover all available information about this medication. It does not cover all possible uses, directions, precautions, drug interactions or adverse effects and is not a substitute for the expertise and judgement of your healthcare professional. Consult your healthcare provider before starting or discontinuing any course of treatment.

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164 Reviews
  • JustMeJustMe
    Similar to the name brand; but much more easy to organize

    My favorite thing about this cold and flu medicine is that it comes in a nice; stackable glass jar and that all the jars this brand offers are compatible. I like that they are square; so space between jars is minimized. Since Cabinet: offers other types of medicines; theoretically; a person could fill all their over-the-counter medical supplies with this unique style of containers. In addition; the brand offers refill pouches for each type of medicine so that the single glass bottle could potentially last a lifetime; reducing waste in the long run.The jar is made of glass; but the lid is plastic. It is a bit difficult to open the jar; but that's a good thing; especially since I have children in the house. The ingredients in the pills are exactly the same as the leading name brand; so I'm confident these will work similarly.

  • Genesis R.
    Medio dificil de abrir

    Es medio difícil de abrir mw gusta pero es medio complicado

  • JetjockJetjock
    Great cold meds; Tricky lid

    I fought with the lid for 15 minutes until I finally PUSHED DOWN and TWISDTED it hard enough to open (I found this explained inside the box after I tore it apart). I use the medicine in these tablets for severe cold symptoms in the winter and am glad to discover that I can get them in this child resistant glass jar. Cabinet's refill program is a great way to keep fresh cold and flu medicine on hand.Expiration date on the jar I got is 3/2024 for 30 tablets. Developed by ACHAL and RUSS to help eliminate the plastic waste and contamination of our planet. You can learn more about their efforts by using the QR code inside the box.

  • Rich M.
    Very Good Cold and Flu Remedy

    These soft gels have the same ingredient lineup as many other non-drowsy capsules and seem to work as well. I like gels rather than tablets because they go down easier and seem to work faster. The packaging is secure; with the gels on a plastic bubble card. The price is right; too. I recommend them.

  • LegoGirlLegoGirl
    As good as Day-Quil

    This generic formulation works as effectively as legit Day-Quil cold capsules. All of the “daytime” medications are less effective than their “nighttime” counterparts; but if you simply can't risk drowsiness then you've got no choice but to use these.Size is pretty much the same as any liqui-gel capsule: photo shows one next to a US nickel coin. The outer shell I agree is a bit harder than some brands I've taken; but I had no problem swallowing them so I don't really think it matters.