Sertraline (generic for Zoloft®)

FDA Approved

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DepressionAnxietyPTSDOCDPanic Disorder
  • Sertraline Hydrochloride

Generic For Zoloft®

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How does Cabinet care for you?

  1. Seamless transfer process. Our pharmacist will coordinate with your current pharmacy or provider to transfer your prescription.

  2. Better for the planet. Our pharmacy will send your prescription refills in plastic-free, compostable pouches.

  3. Stress-free refills. Our care team will help manage your refills and prescription renewals, so you don't have to worry about running out of pills.

  4. Satisfaction guarantee. If your care needs aren't being met, our care team is here and eager to help! If you're not satisfied, we can transfer your prescription back to your old pharmacy at any time.

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Frequently Asked Questions

About the Drug

Sertraline is the generic equivalent of Zoloft®.

By law, a generic drug must be the same as its brand name counterpart in terms of active ingredient, dosage, safety, effectiveness, strength, stability, and quality. A generic may, however, differ in its inactive ingredients (i.e. flavoring, fillers, and preservatives).

Sertraline is FDA-approved for the treatment of:

  • Major depressive disorder (MDD) or depression

  • Obsessive-compulsive disorder (OCD)

  • Panic disorder (PD)

  • Post-traumatic stress disorder (PTSD)

  • Social anxiety disorder (SAD)

  • Premenstrual dysphoric disorder (PMDD)

Sertraline is a selective serotonin re-uptake inhibitor, or SSRI. It works by blocking the brain’s quick absorption of serotonin, a “feed good” chemical in your brain. The end result? An increased level of serotonin in your brain, which is thought to improve mood.

The most common side effects of sertraline include:

  • Nausea, diarrhea, or loss of appetite

  • Sweating

  • Shakiness or tremor

  • Agitation

  • Sleepiness or insomnia

  • Sexual problems, like decreased libido or premature ejaculation

  • Dry mouth

Side effects may improve over time as your body adjusts to the medicine. This list doesn’t represent all possible side effects of sertraline. If you’re experiencing any ongoing, bothersome side effect(s), tell your healthcare provider right away.

If you’d like to learn more, speak with your doctor or pharmacist. The FDA also has a helpful medication guide for sertraline here.

Sertraline (Zoloft®) does come with serious warnings. These include:

  • Increased risk of suicidal thoughts or actions*

  • Serotonin syndrome—a rare, but potentially life-threatening condition that occurs when there’s too much serotonin in the brain

  • Increased chance of bleeding, especially if you’re taking a blood thinner

  • Manic episodes

  • Seizures or convulsions

  • Glaucoma

  • Changes in appetite or weight

  • Low sodium levels in the blood

  • Sexual problems or altered sex drive

If any of the above concern you, speak with your doctor or pharmacist about your perceived risk and other treatment options that exist.

*This warning is a boxed warning. A boxed warning is the most serious type of medication warning assigned by the FDA.

Frequently Asked Questions

Sertraline (Zoloft®) may be taken with or without food.

If you accidentally miss your dose of sertraline, take the dose as soon as you remember. If it’s almost time for your next dose (within 2 hours), skip the missed dose and take your next dose at the usual time.

During pregnancy: Sertraline is considered to be one of the safest options during pregnancy, but risks may still exist.

While breastfeeding: Sertraline is generally considered to be safe to use while breastfeeding, with low levels of the drug found in human milk during studies.

It’s important to treat mental health-related conditions when pregnant or nursing, as untreated depression, anxiety, or other mental illness can harm both you and baby. Always let your provider know if you’re pregnant or breastfeeding, so you can discuss the risks and benefits of starting or continuing sertraline.

It’s recommended to avoid or limit the use of alcohol when taking sertraline. Alcohol can intensify the side effects of sertraline, including dizziness and sleepiness.

Sertraline can interact with some medicines and supplements. It’s always recommended to give both your doctor and pharmacist an updated list of the medicines or supplements you’re taking, so drug interactions can be identified.

Some medicines and supplements sertraline can interact with include:

  • Monoamine oxidase inhibitors (MAOIs): selegiline, phenelzine, linezolid, methylene blue, tranylcypromine, isocarboxazid

  • Pimozide

  • Other SSRIs: citalopram, escitalopram, fluoxetine, paroxetine

  • SNRIs (serotonin and norepinephrine reuptake inhibitors): desvenlafaxine, venlafaxine, duloxetine, milnacipran

  • Tricyclic antidepressants: amitriptyline, doxepin, imipramine, nortriptyline

  • Opioids: fentanyl, tramadol, morphine, codeine

  • Sumatriptan

  • St. John’s Wort

  • Anti-platelets and anti-coagulants: aspirin, clopidogrel, heparin, warfarin

  • Phenytoin

This list doesn’t represent all the drugs that may not be safe to take with sertraline. If you’re unsure whether a certain drug or supplement can be taken with sertraline, speak with your doctor or pharmacist. The FDA also has a helpful medication guide for sertraline here.

FAQs and Drug Facts Medically Reviewed by Joanna Tam, Healthcare and Content Manager

Disclaimer: The information on this page is a summary and is not intended to cover all available information about this medication. It does not cover all possible uses, directions, precautions, drug interactions, or adverse effects and is not a substitute for the expertise and judgment of your healthcare professional. Consult your healthcare provider before starting or discontinuing any course of treatment.

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