Trazodone (generic for Desyrel®)

FDA Approved

Have a prescription? Get your trazodone refills in sustainable packaging with Cabinet Health.
  • Trazodone Hydrochloride

Generic For Desyrel®

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Total Count: 30 tablets
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How does Cabinet care for you?

  1. Seamless transfer process. Our pharmacist will coordinate with your current pharmacy or provider to transfer your prescription.

  2. Better for the planet. Our pharmacy will send your prescription refills in plastic-free, compostable pouches.

  3. Stress-free refills. Our care team will help manage your refills and prescription renewals, so you don't have to worry about running out of pills.

  4. Satisfaction guarantee. If your care needs aren't being met, our care team is here and eager to help! If you're not satisfied, we can transfer your prescription back to your old pharmacy at any time.

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Frequently Asked Questions

About the Drug

Trazodone is FDA approved for the treatment of:

  • Major depressive disorder (MDD) or depression

  • Insomnia—commonly used in lower doses for sleep problems (off-label)

Trazodone is the generic equivalent of Desyrel®.

By law, a generic drug must be the same as its brand name counterpart in terms of active ingredient, dosage, safety, effectiveness, strength, stability, and quality. A generic may, however, differ in its inactive ingredients (i.e. flavoring, fillers, and preservatives).

Trazodone (Desyrel®) does come with serious warnings. These include:

  • Worsening depression; increased risk of suicidal thoughts or actions in young adults*

  • Serotonin syndrome—a rare, but potentially life-threatening condition that occurs when the serotonin levels in the brain are too high

  • Cardiac arrhythmias—problems with your heart rate or heart rhythm

  • Low blood pressure when standing after sitting or lying down (orthostatic hypotension); fainting

  • Increased chance of bleeding, especially if you’re taking a blood thinner

  • Prolonged, painful erections (priapism)

  • Manic episodes or hypomania in patients with bipolar disorder

  • Impaired judgment, thinking, and motor skills

  • Glaucoma

If any of the above concern you, speak with your doctor or pharmacist about your perceived risk and other treatment options that exist.

*This warning is a boxed warning. A boxed warning is the most serious type of medication warning assigned by the FDA.

Trazodone is a serotonin receptor antagonists and reuptake inhibitor, or SARI. How trazodone works isn’t fully understood, but it’s known to block the brain’s quick absorption of serotonin, a “feed good” chemical in your brain. The end result? An increased level of serotonin in your brain, which is thought to improve mood. It also affects other neurotransmitters, which differentiates it from other antidepressants.

The most common side effects of trazodone include:

  • Edema (or swelling)

  • Blurred vision

  • Syncope (or fainting)

  • Drowsiness, tiredness

  • Fatigue, lightheadedness

  • Diarrhea

  • Nasal congestion

  • Weight loss

  • Constipation, dry mouth

  • Trouble sleeping

Side effects may improve over time as your body adjusts to the medicine. This list doesn’t represent all possible side effects (or serious side effects) of trazodone. If you’re experiencing any ongoing, bothersome side effect(s), tell your healthcare provider or seek medical attention right away.

If you’d like to learn more, speak with your doctor or pharmacist. The Food and Drug Administration (FDA) also has a helpful medication guide for trazodone here.

Frequently Asked Questions

Trazodone can interact with some medicines and supplements. It’s always recommended to give both your doctor and pharmacy an updated list of everything you’re taking, so drug interactions can be identified. The FDA also has a helpful medication guide for trazodone here.

If you accidentally miss your dose of trazodone, take the dose as soon as you remember. If it’s almost time for your next dose (within 2 hours), skip the missed dose and take your next dose at the usual time. Don't take 2 doses at the same time or extra doses.

Trazodone can be taken with or without food. If the drug causes stomach upset or dizziness, try taking your dose with a meal or light snack. Make sure to keep food intake with trazodone consistent, as food can change the amount of medicine your body absorbs.

During pregnancy: Studies suggest trazodone can be a safe options during pregnancy, but more research is needed.

While breastfeeding: Similarly, data on trazodone while breastfeeding is limited. ******Research suggests that small amounts of trazodone can enter breast milk, but in levels not expected to cause side effects in nursing infants.

It’s important to treat mental health conditions (and other medical conditions) when pregnant or nursing, as untreated depression, anxiety, or other conditions can harm both you and baby. Always let your provider know if you’re pregnant or breastfeeding, so you can discuss the risks and benefits of starting or continuing trazodone. Always let your provider know if you’re pregnant or breastfeeding, so you can discuss the benefits and risks of starting or continuing trazodone.

It’s recommended to avoid or limit the use of alcohol when taking trazodone. Alcohol can intensify the side effects of trazodone, including dizziness and sleepiness.


All prescriptions are filled at HealthHavenRx - our partner pharmacy and the only pharmacy that can fill prescriptions in our sustainable pouches! If you need to contact them, please call them at the number below.


Toll-Free: 1-877-289-2839

1 Chestnut Street, Suite 3Y
Nashua, NH 03060​


Toll-Free: 1-877-289-2839

1 Chestnut Street, Suite 3Y
Nashua, NH 03060​

A prescription transfer is what happens when you switch pharmacies. During the transfer process our partner pharmacy will contact your existing pharmacy to move your prescription over.

For now, we partner with a cash-pay only pharmacy. In many situations the prices are less than your copay!

Not yet, but we're working on it! In the meantime, you can place and order and get a receipt from your account portal to send in for reimbursement.

Absolutely! Please email our pharmacy team at and we'll get right back to you.

Generally, our partner pharmacy can fill most non-controlled, oral dose prescriptions in Cabinet's compostable refill pouches. They currently do not fill liquid, cream, or compounded medications. We'll contact you directly if the pharmacy has any issue transferring your prescription.

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FAQs and Drug Facts Medically Reviewed by Medical Writing Team, Supported by PharmDs

Disclaimer: The information on this page is a summary and is not intended to cover all available information about this medication. It does not cover all possible uses, directions, precautions, drug interactions, or adverse effects and is not a substitute for the expertise and judgment of your healthcare professional. Consult your healthcare provider before starting or discontinuing any course of treatment.

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