Sertraline (generic for Zoloft®)

FDA Approved

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  • Sertraline Hydrochloride

Generic For Zoloft®

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  1. Seamless transfer process. Our pharmacist will coordinate with your current pharmacy or provider to transfer your prescription.

  2. Better for the planet. Our pharmacy will send your prescription refills in plastic-free, compostable pouches.

  3. Stress-free refills. Our care team will help manage your refills and prescription renewals, so you don't have to worry about running out of pills.

  4. Satisfaction guarantee. If your care needs aren't being met, our care team is here and eager to help! If you're not satisfied, we can transfer your prescription back to your old pharmacy at any time.

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Frequently Asked Questions

Frequently Asked Questions

Sertraline can interact with some medicines and supplements. It’s always recommended to give both your doctor and pharmacist an updated list of the medicines or supplements you’re taking, so drug interactions can be identified.

Some medicines and supplements Sertraline can interact with include:

  • Monoamine oxidase inhibitors (MAOIs): selegiline, phenelzine, linezolid, methylene blue, tranylcypromine, isocarboxazid

  • Pimozide

  • Other SSRIs: citalopram, escitalopram, fluoxetine, paroxetine

  • SNRIs (serotonin and norepinephrine reuptake inhibitors): desvenlafaxine, venlafaxine, duloxetine, milnacipran

  • Tricyclic antidepressants: amitriptyline, doxepin, imipramine, nortriptyline

  • Opioids: tramadol, morphine, codeine

  • Sumatriptan

  • St. John’s Wort

  • Anti-platelets and anti-coagulants: aspirin, clopidogrel, heparin, warfarin

  • Phenytoin

This list doesn’t represent all the drugs that may not be safe to take with Sertraline. If you’re unsure whether a certain drug or supplement can be taken with Sertraline, speak with your doctor or pharmacist. The FDA also has a helpful medication guide for Sertraline here.

If you accidentally miss your dose of Sertraline, take the dose as soon as you remember. If it’s almost time for your next dose (within 2 hours), skip the missed dose and take your next dose at the usual time. If you've just started Zoloft, ensure you keep time of day in mind as it has been associated with insomnia while getting started.

Sertraline (Zoloft®) may be taken with or without food.

During pregnancy: Sertraline is considered to be one of the safest options during pregnancy, but risks may still exist.

While breastfeeding: Sertraline is generally considered to be safe to use while breastfeeding, with low levels of the drug found in human milk during studies.

It’s important to treat mental health-related conditions when pregnant or nursing, as untreated depression, anxiety, or other mental illness can harm both you and baby. Always let your provider know if you’re pregnant or breastfeeding, so you can discuss the risks and benefits of starting or continuing Sertraline.

It’s recommended to avoid or limit the use of alcohol when taking Sertraline. Alcohol can intensify the side effects of sertraline, including dizziness and sleepiness.

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FAQs and Drug Facts Medically Reviewed by Medical Writing Team, Supported by PharmDs

Disclaimer: The information on this page is a summary and is not intended to cover all available information about this medication. It does not cover all possible uses, directions, precautions, drug interactions, or adverse effects and is not a substitute for the expertise and judgment of your healthcare professional. Consult your healthcare provider before starting or discontinuing any course of treatment.

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